J Matern Fetal Neonatal Med. PubMed  Epub 2008 Sep 23. NLM 1997;52:187–91. Prenatal or postnatal cytogenetic examination was performed in three pregnancies, two as prenatal and one as postnatal investigations. Terms and Conditions, CAS  Last, the results obtained in the present study might have been affected by the non-mosaicism-related individual factors given that some patients included had more than one pregnancy as we stressed that 16 cases experienced 52 pregnancies. 2011;95(5):1788–e1-3. Turner syndrome (TS), characterized by a total or partial absence of one X chromosome, affects one in 2,500–5,000 live born girls. SPSS version 15.0 (Statistical Package for Social Science, Spss Inc. Chicago, IL, USA) was used for statistical analysis. Hereditary in nature was reported in mosaic TS cases and especially cases with ring chromosome [10, 41]. Guttenbach M, Koschorz B, Bernthaler U, Grimm T, Schmid M. Sex chromosome loss and aging: in situ hybridization studies on human interphase nuclei. Review. Spontaneous pregnancies are very rare (2%) in women with Turner syndrome [1], and primarily occur when the syndrome is associated with an X anomaly (number or structure) and mosaicism. Time to consider ovarian tissue cryopreservation for girls with Turner's syndrome: an opinion paper. Clipboard, Search History, and several other advanced features are temporarily unavailable. Philadelphia: WB Saunders; 1992. p. 132–64. Here, we report a fetus with a mosaic karyotype: mos 45,X/46,X,del(Y)(q11.21). It is believed that this value may be underestimated, since few studies have investigated primarily spontaneous pregnancy in this genetic condition, and many TS patients may not have been diagnosed because of the wide phenotypic variability associated with this chromosomal abnormality. As previously mentioned, mosaic type of Turner syndrome is characterized by the absence of the sex chromosome in some cells and its presence in others. Mosaicism ratio was given by the assessment of 100 metaphase plaques in all cases in our study, and it should be considered that FISH method was not used while evaluating our results. [Procreation in Turner's syndrome: which recommendations before, during and after pregnancy?]. Brooke TV 3,566 views. Although correlation between genotype and phenotype is not well understood, mosaic cases present milder phenotypic abnormalities compared to those with 45,X karyotype [9]. There are many other symptoms or characteristics that can affect girls and women with Turner syndrome. In 2% of women, spontaneous pregnancy can occur. They don’t happen because of anything the parents did or didn’t do. there were 45,X/46,XX mosaicism in 25 out of 27 Swedish women with TS. Turner syndrome. Many of the women with TS are diagnosed in childhood due to their short stature. Assisted conception techniques, such as egg donation and in vitro fertilisation (IVF), may be recommended for women with Turner syndrome who want to have children. Does 45, X/46, XX mosaicism with 6–28 % of aneuploidy affect the outcomes of IVF or ICSI? In Gorlin’s syndromes of the head and neck. percentage of cases with mosaic karyotype was found to be 45 % only with karyotyping but it reached to 70 % when FISH was used [3]. 2014;27:274–7. Given that the chromosomal aberrations arise possibly from the transmission of the imbalances in the genetic arrangements in mother to the offsprings (10), genetic counseling should be offered to all who conceived with autologous oocytes (11). eCollection 2019. Hum Reprod. Epub 2008 Aug 15. CAS  Diagnosis of Turner's syndrome may be … 2019 Dec 11;9(12):e030855. 1999;14:2257–63. Spontaneous puberty : occurs in 5-10% of young women with Turner's Syndrome & 2-5% of those become pregnant spontaneously. Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. Most instances of Turner syndrome are not inherited. Chromosome abnormalities in 447 couples undergoing intracytoplasmic sperm injection–prevalence, types, sex distribution and reproductive relevance. This syndrome is also referred to as Mosaic Turner Syndrome and Ullrich-Turner Syndrome and is a genetic condition that affects the sexual development in females. The pregnancies carry high risks and have to be followed up carefully. Fortunately, there are fertility treatments available to help increase your chances of having a baby. Fertil Steril. TS patients may experience complications during pregnancy due to congenital malformations and endocrine diseases, and should be evaluated for the presence of these pathologies before IVF or pregnancy [7]. Turner's syndrome can be transmitted from mothers to daughters (Varela et al., 1991; Verschragen-Spae et al., 1992; Blumenthal and Allanson, 1997; Tarani et al., 1998). In addition, one patient underwent hysteroscopic septum resection for uterine septum, another case underwent Strasmann metroplasty for bicornuat uterus and one underwent hysteroscopy and cavity expansion with fundal and lateral incisions for T-shaped uterus. ; TODO: Email modal placeholder 12 ; 148 ( 24 ):1208-10 comparison of parametric.... Is obvious that it is therefore important that women with Turner 's syndrome: reason!, Bryman I, Hanson L. spontaneous pregnancies in mosaic turner syndrome and pregnancy with Turner 's syndrome a... 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