Far less attention has been paid to β-thalassemia minor, the heterozygous state. Thalassaemia is often detected during pregnancy or soon after birth. The American College of Obstetricians and Gynecologists (ACOG) has released recommendations for screening and clinical management of hemoglobinopathies during pregnancy. [Guideline] Angelucci E, Barosi G, Camaschella C, et al. Screening during pregnancy Useful resources in a variety of languages can be found on: www.thalassemia.org. Thalassemia is an inherited (i.e., passed from parents to children through genes) blood disorder caused when the body doesn’t make enough of a protein called hemoglobin, an important part of red blood cells. The low MCV in thalassaemia can be misdiagnosed as iron deficiency. Prenatal diagnosis for ATM is usually done either by chorionic villus sampling (CVS), performed between 10 weeks and 14 weeks of gestation, or by amniocentesis, performed after 16 weeks gestation. People with thalassemia minor or trait usually do not need blood transfusions because they either do not have anemia or have only a mild anemia. SCD affects pregnancy and how pregnancy affects sickle cell disease, and how to improve outcomes for mother and baby. Thalassemias occur when the production of hemoglobin, a protein that carries oxygen within the red blood cells (RBCs) is disrupted. Anaemia in pregnancy is a significant global health problem, with 38.2% of women worldwide affected, 1 predominantly because of iron deficiency. Thalassemia intermedia (TI) is a clinical definition which represents a wide spectrum of thalassemia genotypes but mainly includes patients who do not require or only occasionally require transfusion. The changing profile of homozygous beta-thalassemia: demography, ethnicity, and age distribution of current North American patients and changes in two decades. Couples at risk for alpha thalassemia in pregnancy have the option to pursue prenatal diagnosis to determine whether their fetus has ATM. 3. –α/αα Asymptomatic normally. This consultation should include optimisation of management and screening for end organ damage. . occur during the pregnancy, and the time constraint for obtaining screening results may result in psychological distress. 2011;(10):CD003094. Thalassemia is not an easy disease to live with and makes pregnancy difficult. With proper advice and monitoring, … The chances of having a child with thalassaemia major remain one in four (25 per cent) with each pregnancy. Pediatrics 1996; 97:352. Not much complication is expected in those with minor thalassemia except for increase need for blood transfusion. It focuses on women who give birth between 37 and 42 weeks of pregnancy (‘term’). • Newborns of women with thalassemia should have testing for similar thalassemia conditions in the first year of life. Fertility in beta thalassaemia major: a report of 16 pregnancies, preconceptual evaluation and a review of the literature. Pregnancy in women with thalassemia: challenges and solutions George Petrakos, Panagiotis Andriopoulos, Maria Tsironi Department of Nursing, University of Peloponnese, Sparta, Greece Abstract: Advances in treatment of thalassemia have lead to the aging of thalassemic patients, and consequently concern about successful reproductive outcome is augmented. In thalassemia major, the patient will require blood transfusion after one year of life, when foetal haemoglobin is switched to an abnormal adult form. Beta thalassemia can cause damage to the liver and other organs, and pregnancy puts added strain on your liver. [Guideline] Tubman VN, Fung EB, Vogiatzi M, Thompson AA, Rogers ZR, Neufeld EJ, et al. The guideline helps women to make an informed choice about where to have their baby. 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